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Renovator & Remediate for Joint Health

Renovator & Remediate

RENOVATOR

Renovator is a combination of nutrients to support joints with increases of lubricants (HA) in the synovial fluid and sulfates for cartilage

Help your body strengthen, protect, and rebuild joint tissues

  • Helps strengthen cartilage and maintain structural integrity of joints and connective tissues*
  • Protects joints from harmful free radicals that accelerate the breakdown of connective tissues*
  • Provides nutrients for joint fluid, cartilage, ligaments, tendons, membranes and blood vessels*
  • Increases lubrication and padding for improved mobility*

Build healthy joints for flexible, free movement

The scientists at SISEL have formulated Renovator, a powerhouse product, which supports our bodies’ mobility. Renovator combines glucosamine sulfate with Cynatine FLX™, a powerful new polypeptide extracted from keratin, to support healthy cartilage, plus zinc, selenium, and copper to nourish and build joint tissues, and manganese, beta-carotene, and vitamin C to reduce oxidative damage in our joints.

Many clinical trials have shown glucosamine sulfate to improve joint health, mobility, and flexibility, but may need additional ingredients to maximize its benefits. As we continue to take a daily dose, we assist our bodies in the proper maintenance of our connective and shock-absorbing tissues.1, 2, 3

Cynatine FLX™ helps to calm joint tissues, minimize joint breakdown, and build joint resilience. This new keratin joint ingredient activates two important joint antioxidant defense enzymes—glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD)—to improve the body’s ability to produce glutathione, the body’s own antioxidant defense mechanism. It also provides excellent, direct antioxidant protection and stimulates the regeneration of cells. Keratin is a polymer-forming protein, and joints use polymers to absorb shock and keep the joint together. Finally, Cynatine FLX™ is a fibrous protein that serves as structural units for various living tissues, providing a strong matrix for connective tissues.4, 5

Additionally, Renovator provides vitamins and minerals that contribute to joint health. Studies have shown that taking beta-carotene may reduce the risk of the progression of joint problems.6 Vitamin C is necessary to form collagen and is essential for the repair and maintenance of cartilage, thereby reducing the risk of joint problems.6 Manganese deficiency appears to be a factor in bone loss and degenerative joint conditions.7 Epidemiological studies show a relationship between low selenium and decreased joint health.8, 9 Zinc is involved in making up cartilage collagen.10, 11 Copper is needed for effective cross-linking of collagen and elastin.12

References:

1 Pavelka K, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med. 2002 Oct 14:162(18):2113-23.

2 Bruyere O, et al. Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies. Menopause 2004;11:138-43.

3 Reginster JY, et al. Long-term effects of glucosamine sulfate on osteoarthritis progression: a randomized, placebo-controlled trial. Lancet 2001;357:251-6.

4 A Ostalowska, E Birkner, M Wiecha, et al. Lipid peroxidation and antioxidant enzymes in synovial fluid of patients with primary and secondary osteoarthritis of the knee joint, Osteoarthritis and Cartilage, Volume 14, Issue 2, Pages 139-145

www.nutraingredients.com. A Pure, Potent Joint Health Alternative, includes links to Cynatine’s clinical and background documentation, 2005.

6 McAlindon TE, et al. Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis?Arthritis Rheum 1996;39:648-56.

7 Das A Jr, Hammad TA. Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis. Osteoarthritis Cartilage. 2000 Sep;8(5):343-50.

8 Jellin, Jeff M. PharmD, Founding Editor. 3120 W. March Lane, PO Box 8190, Stockton, CA 95208, Tel:(209) 472-2244 Fax:(209) 472-2249. Copyright © 1995-2007 Therapeutic Research Faculty, All rights reserved.

9 Jordan JM, Fang F, Arab L, et al. Low selenium levels are associated with increased risk for osteoarthritis of the knee.American College of Rheumatology Annual Meeting. San Diego November 12-17, 2005. Abstract 1189.

10 Rosenberg K, et al. Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen.J Biol Chem. 1998 Aug 7;273(32):20397-403.

11 Leppanen VM, et al. Crystal structure of the N-terminal NC4 domain of collagen IX, a zinc binding member of the laminin-neurexin-sex hormone binding globulin (LNS) domain family. J Biol Chem. 2007 Aug 10:282(32):23219-30.

12 National Acadamies Press. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc (2000). Food and Nutrition Board (FNB). Institute of Medicine (IOM). Web: http://www.nap.edu/openbook.php?record_id=10026&page=224.


REMEDIATE

*Remediate is an anti-inflammatory to reduce swelling and inflammation pressures on pain receptors as it decreases damage to the joints

SISEL’s formulators have created Remediate—a powerful combination of ingredients, featuring 5-Loxin and Cat’s Claw—to care for our bodies’ joints. 5-Loxin is made from the gum resin of Boswellia serrata, commonly known as Indian frankincense. Remediate has 15 times more of the boswellic acid AKBA than natural Boswellia serrata, and AKBA supports joint health.1 5-Loxin inhibits the enzyme 5-lipooxygenase and reduces the enzyme matrix metalloproteinase—both enemies of healthy joints.2 In one study, 50 mg twice daily of 5-Loxin showed clinically and statistically significant support for subjects’ joint function—48%, 24% and 40% (compared with placebo).3

Remediate contains a bark extract of Cat’s Claw, a vine found and used in the Amazon River basin. Cat’s Claw has been found to support cellular signaling and improve measurements of joint health.4 In one study, 60 mg daily of Cat’s Claw extract for 24 weeks contributed to joint health by 53% compared to 24% with placebo).5 In another study, 100 mg daily of Cat’s Claw extract for just 4 weeks significantly supported joint health by 39% (compared to 12% with placebo).6

·       Highly concentrated active ingredients showing clinically and statistically significant contributions to joint health and physical function*

·       Contains concentrated AKBA(5-Loxin), the most powerful compound from Boswellia serrata or Indian frankincense, commonly used in Ayurvedic medicine*

·       Seventy patients completed the study. At the end of the study, both doses of 5-Loxin® conferred clinically and statistically significant improvements in pain scores and physical function scores in OA patients. Interestingly, significant improvements in pain score and functional ability were recorded in the treatment group supplemented with 250 mg 5-Loxin® as early as 7 days after the start of treatment. Corroborating the improvements in pain scores in treatment groups, we also noted significant reduction in synovial fluid matrix metalloproteinase-3. In comparison with placebo, the safety parameters were almost unchanged in the treatment groups.

·       Conclusion

·       5-Loxin® reduces pain and improves physical functioning significantly in OA patients; and it is safe for human consumption. 5-Loxin® may exert its beneficial effects by controlling inflammatory responses through reducing proinflammatory modulators, and it may improve joint health by reducing the enzymatic degradation of cartilage in OA patients.

·       Contains Uncaria tomentosa or Cat’s Claw from the Amazon River basin, used in traditional Peruvian medicine*

·       Cat’s claw is thought to have anti-inflammatory effects and has been used for rheumatoid arthritis and osteoarthritis. Compounds in cat’s claw are thought to block the body’s production of inflammation-producing substances called prostaglandins and tumor necrosis factor (TNF). Cat’s claw is believed to reduce pain somewhat, but it doesn’t appear to have much of an effect on reducing swelling. More evidence is needed before cat’s claw can be used as a treatment for arthritis.

·       Protects collagen*

Remediate also contains:

·       Devil’s Claw to improve the vitality of the joints*

·       Ginger extract, long used in Ayurvedic medicine around the world, and currently on the FDA’s “generally recognized as safe” list*

·       Curcumin, from the widely used Indian Ayurvedic medicine, Turmeric. Recent in vitro and animal studies on curcumin have suggested a wide range of benefits, prompting numerous clinical trials in humans. *

·       Willow Bark extract, which contains salicylic acid*

·       Nettle extract, beneficial to the synovial tissue that lines the joints*

·       Green Lipped Mussel, which contains a unique combination of fatty acids not found in any other marine or plant life, including glycosaminoglycan which supports healthy joints*

*Remediate is an anti-inflammatory to reduce swelling and inflammation pressures on pain receptors as it decreases damage to the joints

References:

www.5-loxin.com, Why is it special?

2 Sengupta K, et al. Study of the efficacy and safety of 5-Loxin, p. 4, 14, 2007

3 Sengupta, p. 2, 7, 11.

4 Hardin SR. Cat’s Claw: an Amazonian vine, p. 26, 2007

5 Mur E, et al. Double blind trial of Uncaria tomentosa, p. 678–9, 2002 and Jellin, JM. Founding Editor Natural Medicines Comprehensive Database, p. 1, 4

6 Piscoya J, et al. Efficacy and safety of freeze-dried cat’s claw, p. 443–4, 2001 and Jellin, p. 1, 4

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Connie Clark
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